In today’s world we have become much more aware of the damage that can be done to the environment due to the release of chemicals into the air or water courses. Therefore, it is necessary to obtain suitable information on the potential to damage the environment as soon as is possible. C3-B can look into the potential for environmental hazard by performing suitably selected, laboratory tests that can determine how a chemical behaves in the environment.

The amount of information required will depend upon the anticipated level of manufacture of the product, from Level VIIC with an annual quantity of > 10 kg, through Level VIIA (often referred to as the Base Set level) to Level 2 with annual quantities > 1000 tonnes. The majority of tests are performed as per Annex V, Part C of the Dangerous Substances Directive 67/548/EEC. Many of the tests are also listed under the proposed REACH scheme.

Thus the detrimental effect that a chemical has on fish life, algae or crustacea needs to be considered along with how the material is able to degrade in its environment, normally as a waste product or accidental release. If a material does not degrade rapidly then there is also a risk of the material accumulating and presenting a greater risk to the environment.

Eco-Toxicological Tests

EU Ref. OECD Ref. Test Description
C1 203 Acute toxicity fish
C2 202 Acute toxicity Daphnia
C3 201 Algal growth inhibition study
C11 209 Activated sludge respiration inhibition
C4 301 Ready Biodegradability
C7 111 Hydrolysis as a function of pH
C19 117 Adsorption/Desorption (HPLC test)

Test Methods are provided by the EU and OECD (Organisation for Economic Co-operation and Development) guidelines, green and yellow pages which are also known as the 200 and 300 series respectively.


All Eco-Toxicological work performed by Brixham Enviromental Laboratories.

 

C3-B is an informal collaboration between AstraZeneca UK Limited (Brixham Environmental Laboratory), Chilworth Technology Limited, Centre de Recherches Biologiques (CERB) and Chemsafe S.a.S. No legal relationship exists between the aforementioned entities and none of them has the authority to contract on behalf of any other of the entities.